The buzz surrounding this movie is massive. Man of Steel was a polarizing movie and this movie seems to also be polarizing and very controversial with fans. That controversy will pay off at the box office as everyone will want to see it regardless of the quality. Man of Steel made a good amount of money and this being the first movie with Ben Affleck as Batman I think everyone will want to see his performance as the caped crusader. Warner Brothers is betting everything on this movie being a huge movie to launch it's DC movie universe and the hype surrounding this movie is massive and all but guaranteed to be 2016's biggest, most talked about movie of the year.
Honorable Mention :
Doctor Strange
I hate to bet against a Marvel cinematic universe movies but Doctor Strange might not be a huge hit with audiences because the storyline is so mystical and simply too weird . Sadly the box office has an ugly history with many movies failing with similar spiritual themes. Will it be able to connect with general audiences or will it be only a fan favorite? Sadly this character is obscure and I imagine this movie not being a huge success and potentially being the first flop in the Marvel cinematic universe.